Latest Posts

Natural Stacks Launch Sale + Episode #21 Corrections

As promised in Episode #21, here’s some new intel on the “launch sale” for Natural Stacks, the new nootropics company from the episode guests Abelard Lindsay and Roy Krebs.

A Note from Jesse: The Natural Stacks guys were nice enough to offer me a commission on sales that come their way from Smart Drug Smarts listeners. I thought about it, and my policy in situations like this will be to provide two links – one “affiliate link” where I’ll get a referral commission on sales, the other a plain-old normal link, the same as if you typed their website name into your browser yourself. It’s totally up to you, and I plan to keep Smart Drug Smarts first and foremost an information hub, not a marketplace. Launch Offer

From now until October 16th, all CILTEP purchases also include a free bottle of SMART CAFFEINE (caffeine + l-­theanine).

SMART CAFFEINE can be stacked with CILTEP for the ultimate focus boost.

One month’s supply of CILTEP and SMART CAFFEINE (120 total capsules) for only $42.95 with free shipping.

View Offer [referral] | View Offer [no referral]

Also, Abelard was both kind and thorough enough to do some post-interview research and wanted to add some corrections to the points he made during the episode. His amendments are below:


Correction #1:

Viagra inhibits PDE5 which breaks down cGMP (Cyclic guanosine monophosphate ) which is a secondary messenger as cAMP, is but is not the same as cAMP.

“Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide-derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP.” …
“Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5’­ GMP. PDE 5, ­6 and ­9 are cGMP­specific while PDE1, ­2, ­3, ­10 and ­11 can hydrolyse both cAMP and cGMP.” …
“Sildenafil (Viagra) and similar drugs enhance the vasodilatory effects of cGMP within the corpus cavernosum by inhibiting PDE 5 (or PDE V)”

Correction #2

Another mistake I made was saying that acetyl-l-carnitine lowers or inhibits acetylcholinesterase. Its mechanism of action is actually increasing levels of acetylcholine in the brain which helps mitigate the increased activity of acetylcholinesterase which breaks down acetylcholine.

Acetyl­L­carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats.
Acetyl­L­carnitine as a precursor of acetylcholine.

Correction #3

One last mistake is that cAMP does not directly increases acetylcholinesterase. The study I found said that forskolin was observed to increase acetylcholinesterase levels and cAMP, but wasn’t specific on how it did it, nor did it say it did it via an increase in cAMP.

Forskolin, an inducer of cAMP, up-­regulates acetylcholinesterase expression

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Scroll to top