Brain Health,

#052: Mimicking Caloric Restriction with Oxaloacetate

November 17, 2014

In Episode #52, we’re joined by Alan Cash, physicist and entrepreneur behind benaGene Advanced Anti-Aging supplement. Alan introduces us to benaGene’s active ingredient – oxaloacetate – and talks us through its positive CRON (Calorie Restriction with Optimal Nutrition)-mimicking effects on everything from lifespan to Type 2 diabetes.

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Show Notes
  • 00:00:32

    Introduction to Alan Cash and CRON (Calorie Restriction with Optimal Nutrition)

  • 00:01:32

    This Week in Neuroscience: High-Fat Diet Postpones Brain Aging In Mice

  • 00:04:27

    Thank you for your emails (and sign up to receive some from us)!

  • 00:05:50

    Intro to benaGenea and Terra Biological

  • 00:06:28

    What is caloric restriction?

  • 00:09:36

    Unexpected effects on energy levels, and changes in gene expression

  • 00:13:04

    Energy pathways, the Krebs cycle, and oxaloacetate

  • 00:18:05

    Type 2 diabetes and bringing oxaloacetate to the market

  • 00:24:47

    Oxaloacetate levels contained in benaGene versus in a standard diet

  • 00:28:04

    Patient-Inspired Parkinson's trial

  • 00:30:44

    Oxaloacetate study: effects on brain mitochondrial biogenesis, insulin pathways, inflammation, neurogenesis, sort-term memory, and hippocampal plaque density

  • 00:32:32

    CRONaxal: Oxaloacetate treatment for brain cancer

  • 00:34:30

    Ruthless Listener-Retention Gimmick: Mind-Blowing Robot Conjures Ghosts In The Lab


  1. Thanh Hoang Ngoc says:

    Great Post

  2. ben says:

    If seems malate is what’s important to activate AMPK / DAF-16, so is it possible to supplement with malate directly rather than via oxaloacetat acid (OAA) to malate? Or is the malic acid (L-Malic acid / L-aspartic ) from green apples / supplements / mitochondria rich foods, not the same? Curious since the conversion from oxalacetic may vary widely among people/ages,

    Finally, the results of the Parkinsons study by Kansas University (mentioned near the end of the episode) is now available (NCT01741701)

    Jesse, you promised to post in the this episodes’ show notes and/or in the next episode, what Alan has personally noticed from taking oxaloacetate, but I don’t see that anywhere!

    Regarding ghosts in the lab, there was a great You Are Not So Smart podcast episode (42), where they do a similar experiment, there’s also video of it on the Ellen DeGeneres show “Brain Games”!

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