Smart Drugs,

#069: Ritalin: On and Off-Label

March 28, 2015

For Episode #69, we welcome back Dr. Jehangeer Sunderji, of Mind Body Medicine in Santa Monica, California, to speak about a household name among cognitive enhancers: Ritalin.  Dr. Sunderji runs through the benefits – as well as the risks – of this powerful smart drug and stimulant, and advocates the importance of careful diagnosis and responsible dosing.

We’ll also hear about how our genetic make-up greatly influences how likely we are to suffer from anxiety – and how that can lead to our attraction to drugs and addiction.  Finally, Jesse rolls his eyes at a brain-controlled fashion accessory that can show those around us how we feel… if they happen to be looking at our butts.

Show Notes
  • 00:00:32

    Welcoming back Dr Jehangeer Sunderji for our long awaited Ritalin (methylphenidate) episode

  • 00:01:26

    This Week in Neuroscience: The Feel-Good Gene

  • 00:03:17

    Audience thank-yous

  • 00:03:53

    Jesses update on his ketogenic diet experiment

  • 00:05:21

    DIY biohacking communities 

  • 00:06:01

    Methylphenidate drawbacks and benefits (also mentioned in Episode 65: CANTAB – Quantified Cognition

  • 00:07:11

    What is methylphenidate – how does it work, what is it used for, and why was it invented?

  • 00:08:45

    Ritalin vs Adderall

  • 00:10:30

    Factors effecting how individuals react to Ritalin

  • 00:12:00

    How Ritalin effects the brain structure of people diagnosed with ADHD vs those who are misdiagnosed 

  • 00:13:23

    Habit-forming differences between Ritalin and Adderall 

  • 00:14:24

    Methylphenidate on the gray market  

  • 00:15:19

    The physiological side-effects of Ritalin, and how cravings for other substances can be triggered by activating addiction-based circuitry 

  • 00:16:53

    Differences in product formulation from country to country

  • 00:18:11

    ADHD-drug dosing – what excessive amounts can do to your body, how dependencies are formed, and how "drug holidays" work

  • 00:23:13

    Monitoring administration, and the dangers of drug diversion and general misuse 

  • 00:24:47

    Disaster scenarios due to drug (and fruit) interactions

  • 00:26:07

    The trade-offs between Ritalin's undeniable cognitive enhancement properties and the risks involved with taking it 

  • 00:28:50

    Jesses thoughts on Ritalin

  • 00:29:43

    Ruthless Listener-Retention Gimmick: Japanese Neurowear Accessories

One comment

  1. Lukas says:

    Awesome episode Jesse, rly appreciate your podcasts 😉

    Just wanted to ask, you kind of asked Dr. Jehangeer Sunderji about what “normal” dosing would be, but if I listened right he didn’t give you answer.

    Did you talk about this maybe off “podcast” ? For example what would be “common & relatively safe” dose for non ADHD diagnosed ppl for instant release version of Ritalin ?

    Thanks a lot 😉

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