Studies have shown that long term use of MDMA can have a permanent, negative effect on neurotransmitters.  Long term MDMA use is associated with changes in dopamine and serotonin neurotransmission, as well as increasing extracellular levels of norepinephrine.

Source:  The effects of methylenedioxymethamphetamine (MDMA, “Ecstasy”) on monoaminergic neurotransmission in the central nervous system.

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