Brain Health,
Smart Drugs,
28 MINS

#019: Jesse’s Aniracetam Self-Experiment

July 19, 2013

The Smart Drug Smarts podcast is back this week with a new self-experiment by Jesse as he records his own virgin voyage with Aniracetam.*  Aniracetam is the more-potent sibling chemical of Piracetam, with efficacy at the 750-1500 mg/day range, as opposed to Piracetam, which is generally considered to have 2400 mg/day as a bottom-end dosage.  In this episode, Jesse takes 750 mg of Aniracetam and documents his results. He also talks with his friend Ben about Ben’s experience using Modafinil for the first time.

*Aniracetam is a key ingredient in NEXUS, Axon Labs‘ flagship nootropic stack.

Aniracetam and its Benefits

Aniracetam is classified as an ampakine nootropic in the Racetam class. It is one of the more potent drugs in the class, and it’s gotten significant attention in Europe (including getting approved as a prescription pharmaceutical), but hasn’t been approved by the FDA in the United States.

Aniracetam has been reported to yield significant increases in cognitive functioning and abilities. This is further enhanced by its effects on memory recall and, probably more importantly, its high-level effects on learning. To add to that, the drug has been proven as an anxiolytic, a drug which helps reduce anxiety.

Reported side effects of Aniracetam vary widely, but the most commonly noted are insomnia, headaches, anxiety, pain, vertigo, nausea, and diarrhea. Many people report experiencing zero negative side-effects after taking a regular dose of Aniracetam, but the validity of these claims is definitely in question.

The standard recommended effective dose is 750 mg, but again, as with other aspects of the drug, this is widely debated.  Most forms of Aniracetam come in a 500 mg pill.

Jesse’s Effects

Following the common recommendations, Jesse swallows a 750 mg pill.  After only one hour, he starts to experience some subtle feelings of being on point and more focused.  At first, he notes that he’s not sure that it’s the drug, but it’s a feeling, nonetheless.

About two hours in, Jesse reports some interesting findings.  He recognizes that he’s feeling wired and restless.  He’s jumping from task to task, in what he calls a “multitasking frenzy.”  Although he doesn’t consider it bad, it’s at least weird, and worth noting.  Luckily, there’s no adverse effects on his appetite, as he’s chowing down on almonds while recording the episode.

Four and a half hours in and Jesse has big news. He feels that he’s sustained a high level of focus and interest in what he’s doing.  He’s not 100% convinced that it was the Aniracetam that caused the notably productive work session, but the results were significant enough that he calls the experiment a Round 1 success, and definitely worth giving another go in the near future.

This Week In Neuroscience: BBC News – Late Nights “Sap Children’s Brain Power’

Professor Amanda Sacker from University College London and her team conducted a study of the effects of sleep schedules on children’s minds. The test involved over 11,000 kids aged 3, 5, and 7 and showed interesting results.

Kids who went to bed earlier and at the same time nightly ended up scoring far higher on their math and reading tests. This might be caused by the disruption of the body’s natural rhythms, and because of this, it impairs the mind’s natural ability to learn and retain memory. The test did take into consideration the children’s home situations (more “organized” parents enforcing both bedtimes and better learning habits), but it’s tough to know if this confounding factor has been entirely mitigated.

Read the original article here.

Key terms mentioned

16 comments

  1. Tom says:

    WOW 800 mg modafinil is a lot!
    Didn’t you have any skin reaction like itchiness, red spots? there is a lot of scare about skin reactions with modafinil.

  2. Tom says:

    WOW 800 mg modafinil is a lot!
    Didn’t you have any skin reaction like itchiness, red spots? there is a lot of scare about skin reactions with modafinil.

  3. Damon says:

    You know how it goes Jesse, under-promise and over-deliver. That’s all you need do.

  4. Damon says:

    You know how it goes Jesse, under-promise and over-deliver. That’s all you need do.

  5. QueueueQueue says:

    Is this podcast not doing any more episodes ? 🙁

    1. Jesse Lawler says:

      Hi there Jason – Happy to report that more episodes aren’t far off! Massively sorry about the long delay (we can call it a “summer vacation”, although a vacation it wasn’t). Thanks for bearing with me. – Jesse

  6. QueueueQueue says:

    Is this podcast not doing any more episodes ? 🙁

  7. Frank says:

    Hi Jesse, great podcast. From my research (link in site field) I’ve found that in order to get the full effects of Aniracetam you must take it with a fat source and choline. I’m curious to know if you’ve approached it this way or if you’ve taken it with another nootropic yet?

    1. Jesse Lawler says:

      Hi there Frank – So far the only other nootropic (well, borderline so) that I’ve done Aniracetam in conjunction with is good ol’ caffeine — which for what it’s worth, I thought performed well together. But thanks for the note on this. Next time I’m feeling like taking Aniracetam (which I think I’ll be using more for brainstorm sessions than for focus) I’ll try it with a big plate of scrambled eggs – natural fats plus choline all at once. (Truth is I’m not sure how many eggs it takes to get an effective dose of cholines to balance out a racetam, but hopefully some googling – or perhaps your site – will provide me the answer.)

  8. JPL says:

    I had a similar effect to Ben in reference to modafinil as it relates to brain fog. The kicker is that it only happes to me on the modalert from Sun Pharma in India (the aluminum four pack Ben referenced). When using perscribed Modafinil, I do not get this negative effect. The modalert was so bad for me, that I could not take it either. After several days of taking it, I felt that I had to keep taking it just to stay awake in a normal fashion. On the other hand, regular modafinil worked great with no brain fog or sleepiness. I didn’t feel like I was borrowing ahead as Ben put it as I did on modalert. I also feel like the modafinil has a stronger nootropic effect than the modalert. While I could feel the benefits of the modalert, it wasn’t nearly as strong as the modafinil, even at higher doses. It had a point of diminishing return.

  9. Aaron says:

    Where did you get the aniracetam? What’s the best place to legally get it in the states?

    1. Jesse Lawler says:

      I ordered it from antiaging-systems.com, based out of the UK. To my knowledge, Aniracetam is not FDA-approved in the States… meaning there’s no answer to your second question. It’s available by prescription in Europe.

  10. Aaron says:

    Where did you get the aniracetam? What’s the best place to legally get it in the states?

  11. Dizeeta says:

    I want Aniracetam, Noopept and Alpha GPC. I want to try… But i can’t as it is not legal in India… Can anyone shed some light on this…

  12. Webr says:

    How can I get my hands on some of this

    1. Jesse Lawler says:

      Webr — Aniracetam is sold a lot of places online. I’ve seen it in pill form, in “bulk powder” form, and I can’t neglect to mention that it’s also the centerpiece ingredient in our nootropic mix Nexus, available at AxonLabs.io. 😉

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