Episode 90

So what exactly is Gamma Hydroxybutyrate (GHB)? It’s a naturally-occurring metabolite of the inhibitory neurotransmitter GABA, and is present in small amounts in almost all animals. (Sounds innocuous so far…) But, it has acquired an infamous reputation over the years, and is now a highly controlled substance in most countries. In Episode #90, Jesse takes a deep dive with Dan Pardi into the world of GHB – its development, its promise as both a sleep aid and a physical-health supplement, and its misuse potential and the subsequent ban.

A quick taste of what else is lined up this week: Research about the apparent (and surprisingly) usefulness of mixing pictures of food (nom nom) with disgusting images of multi-legged creepy-crawlies. And if you happen to find yourself in foggy ol’ London, there’s a unique experience that you may want to try…

All this and more in the 90th episode of Smart Drug Smarts.

Episode Highlights

0:32Jesse kicks off the 90th episode with a flashback to the 1st.
1:43This Week In Neuroscience: The power of Disgust on Diet.
3:52The audience interaction section.
4:59A follow-up on Episode 89 - Dr. Eyerman's Music List.
5:22Clash of the Giant Robots.
6:01Visit Axon Labs and check out our stacks.
6:47Jesse introduces Dan Pardi.
7:55Dan shares his background and introduction to GHB.
10:52The imperfect drug.
12:22A discussion about Narcolepsy.
19:25GHB as a health supplement.
20:43The abuse potential.
22:08Dose response and half-life.
22:49GHB as a neurotransmitter.
24:54Misuse of GHB and its' subsequent ban.
28:41A look at current regulations.
32:09The toxicological profile.
33:38Mechanism of action.
38:29Ruthless Listener Retention Gimmick: More than a silver lining.

PS: As the old saying goes, “If one door closes, another opens.” Feed your head and keep your neurons charged with the choicest of neuroscience tidbits by signing up for our newsletter below.

Written by Anushtup Chatterjee
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