Episode 66


As a follow-up to our much-anticipated Water Fast Week, Jesse is joined by Dr. Valter Longo, Professor of Gerontology and Biological Science, and Director of the USC Longevity Institute.  Dr. Longo shares with us his research on the beneficial effects of fasting on everything from our immune responses to our lifespans, and addresses some points of curiosity that arose over the course of our calorie-free week.

A few Smart Drug Smarts listeners  – and Water Fast Week participants – also weigh in on their experiences, and answer a question our friends and family have all been dying to know… Was it worth it?

We’ll also find out just how much of an effect exercise can have on cognition,  and we’ll get a chance to travel back in time to the land of dinosaurs on drugs.

Episode Highlights

0:32Why a "starvation" episode?
1:37This Week in Neuroscience: Physical Exercise Habits Correlate with Gray Matter Volume of the Hippocampus
3:47(Australian) iTunes Review thank-you!
4:50A little background on how this episode came to be (Episode 56: Ketosis Vs Cancer? ), and an introduction to Dr. Valter Longo
7:37Fasting as a way to reboot the immune system
9:11Are there any downsides to performing an immune system "spring clean"?
10:06What is the optimal fasting frequency and length for humans to keep their immune systems in tip-top shape?
12:36What happens in our bodies during low-calorie dieting periods versus during water-only fasts, and the difference between types of caloric ingestion
14:06Pros and cons of water-only fasts, fasts including supplementation, and fasts that still allow for a small amount of caloric ingestion
16:51Intermittent fasting, time-restricted eating, and how Dr. Longo incorporates caloric restriction into his own life
18:49Does the time of day people choose to eat matter?
19:19Effects of fasting on Alzheimer's disease
20:03Ketones: Our alternative fuel-source
21:32What are some of the physiological upsides to being in ketosis?
23:20Jesse's experience during Water Fast Week
25:39Some accounts from the other Water Fast Week participants
28:41A big thank-you for everyone who got involved, and what to do if you want to join in next year!
29:02 Jesse's Water Fast Week Stats
29:29Ruthless Listener-Retention Gimmick: The Connection Between Grass, Dinosaurs, and LSD?
31:14My Own Life – Oliver Sacks on Learning He Has Terminal Cancer
32:02(For Axon users) Show notes online here
Written by Rhiannan Roe
Rhiannan Roe is a writer, editor and unapologetic champion of self-improvement. Combining her passions has led to her helping several start-ups across three continents. In her spare time she travels, collects stories from inspiring people, and fruitlessly endeavors to read every book ever written.
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