Episode 108

For 2015’s year-end finale and Christmas-debuting episode, we talk about hormesis – the idea that in very small doses, “bad” things can be good.  This counterintuitive and controversial idea has been borne out by evidence in areas from immunology to chemical toxicity to — well, almost everywhere researchers have looked. 


Joining Jesse is world-renowned expert, researcher and advocate of hormesis Dr. Edward Calabrese from the University of Massachusetts Amherst.  Learn about the history of hormesis, its surprisingly wide applicability and its slow-but-steady progress towards mainstream acceptance in this episode.

In the Ruthless Listener Retention Gimmick, if you’re sick of Christmas tunes (and who isn’t, by this time of year?) but still want something “feel-good” in your earbuds… Science has come to the rescue.  Researchers have been painstakingly determining the mathematical recipe for a feel-good song.  And we’ve got results.

Episode Highlights

0:38Jesse welcomes you to the Christmas episode.
2:07This Week In Neuroscience: Smarter people live longer.
4:54A follow-up on our recent episode on Synesthesia and a podcast link from the President of the American Synesthesia Association.
6:05The audience interaction section.
7:20Jesse introduces Dr. Edward Calabrese.
9:07What is Hormesis?
10:52Multiplicative factors in Hormetic response and ceiling limit.
14:12Implications for clinical trials.
16:03Mechanism of action.
18:17Historical background of dose response.
22:56Threshold dose response vs Linear dose response
25:01Model validation.
28:30Applications in cognition - Preconditioning.
31:19Current state of affairs with Hormesis.
33:17Jesse's holiday reading recommendation.
34:04Ruthless Listener Retention Gimmick: Are you feeling good yet?

PS:  Hello Audience – this is the Postscript speaking. I appreciate all your support in 2015 and wish you a Merry Christmas and a Happy New Year.  See you smarties again in 2016! 🙂

Written by Anushtup Chatterjee
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