The podcast is the how-and-why Smart Drug Smarts got started. Essentially, Jesse wanted a good excuse to call smarty-pants scientists and have a chat. Difficult to do under normal circumstances; a little easier with a snazzy logo and a $100 microphone.

This page is an archive of our growing treasure-trove of past episodes. Fun-fact for the new listeners: Not all the guests agree with one another on the proper care and feeding of your brain!

Listen with an open mind, discerning ear, and (always important) healthy skepticism.

Episode 54
L-tryptophan and Your Holiday Brain


In Episode #54 – as a special Thanksgiving treat – we’re joined by Professor Gilles Guillemin, world leader in research on
L-tryptophan and neuroinflammation. Professor Guillemin dispels the turkey-makes-you-sleepy myth that often comes up at this time of year, and explains the actual effects of L-tryptophan and its metabolites on our neurochemistry.

Episode 53
Snakes On A Brain!


Jesse speaks to Drew Birnie, Research Scientist and Content Manager at, about “Snake Oil” – the term used to classify fraudulent medicine, or products that claim unverified results.

Episode 52
Mimicking Caloric Restriction with Oxaloacetate


Alan Cash, physicist and entrepeneur behind benaGene Advanced Anti-Aging supplement introduces us to oxaloacetate and talks us through its positive CRON (Calorie Restriction with Optimal Nutrition)-mimicking effects.

Episode 51
The Aquatic Origins Of Your Brain


In Episode #51, Jesse speaks with Dr. Michael A. Crawford of Imperial College London about the role of seafood — and the essential fats they contain — in the evolution, development, and maintenance of our brains. Dr. Crawford shares with us a “coastal evolution theory,” the importance of proper nutrition for brain-health, and how it is our mothers who are most responsible for our cognitive abilities.

Episode 50
The Pain Episode


Professor Lorimer Moseley from the University of South Australia shares with us his extensive knowledge on the way our brains process pain.

Episode 49
Sensory Deprivation Tanks


Jesse speaks to Crash, owner of Float Lab Technologies, a sensory deprivation tank center in Venice Beach, California. Crash explains the ins and outs of the Float Lab experience, and what can happen to our minds when they’re freed from all external distractions.

Episode 48
25 Years of Holosync Meditation


Jesse interviews Bill Harris, meditation guru, founder of The Centerpointe Research Institute, and creator of Holosync Audio Technology. Bill tells us how we can gain more self-awareness in order to exercise choice in our lives, and how Holosync Technology can get us on the fast track to deep-level meditation.

Episode 47
Do You Need a “Living Autopsy”?


Jesse interviews Dr. Eric Braverman, best-selling author of books The Edge Effect and Younger You, and founder of the PATH Medical Center in New York.

Episode 46
Improving on Piracetam with Noopept

Noopept - From Russia with Love to Your Brain

Dr. Rita Ostrovskaya, world-leading expert and co-creator of Noopept, joins us to shed some light on this new-to-the-scene nootropic.

Episode 45
Axon: an App for the Nootropics Community


Jesse discusses the soon-to-be-released mobile app Axon, aimed at the nootropics-loving community in general, and Smart Drug Smarts fans in particular.